Diabetics should understand liver abscess

Diabetes is a group of metabolic diseases characterized by chronic increase in blood glucose levels, while liver abscess is a purulent liver disease caused by bacteria, amoeba protozoa and other microorganisms.

Bacterial liver abscess is a focal accumulation of pus caused by an inflammatory reaction secondary to bacterial infection in the liver parenchyma. Escherichia coli is the more common pathogen of bacterial liver abscess.

The process of liver abscess caused by amoeba protozoa is when people swallow food or drinking water contaminated by amoeba cysts. After digestion by gastric juice, amoeba cysts release protozoa in the intestines. After protozoa multiply, they invade colon mucosa Ulcers are common in the cecum, ascending colon, etc. The amoeba parasitizing the colonic mucosa secretes histolysase, digests and dissolves the small veins on the intestinal wall, the protozoa invades the vein and enters the liver with the venous blood flow. Part of the surviving protozoa reproduce in the liver, dissolve the liver tissue and form an abscess.

There are also some unexplained liver abscesses called cryptogenic liver abscesses, which may be related to hidden lesions that already exist in the liver. When the body’s resistance is weakened, pathogenic bacteria will multiply in the liver, causing liver abscess.

The clinical manifestations of liver abscess are mainly atypical infections such as fever, elevated white blood cell concentration and high C-reactive protein. Without timely treatment, the condition may get worse at any time and even lead to death of the patient.

There is no direct causal relationship between liver abscess and diabetes, but patients with diabetes have metabolic disorders that are difficult to change and reduced resistance. Bacteria invade the body and easily cause systemic purulent infections. Once bacteria flow into the liver, they multiply in the liver and cause a bacterial liver abscess. Bacterial liver abscess has a higher incidence in diabetic patients, and it is much higher than that in non-diabetic patients.

Studies have shown that aging, sepsis, tuberculosis, glycosylated hemoglobin, and hypoalbuminemia are all related factors of diabetic liver abscess. Gender, chronic complications of diabetes, biliary tract infection, abnormal liver function are not related to diabetic liver abscess.

Diabetes with liver abscess
Clinical manifestations and harm
Diabetes patients often have vascular and neuropathy, which can lead to decreased pain sensitivity, atypical local symptoms and signs, and accompanied by other systemic diseases, it is easy to cover the condition of bacterial liver abscess, and it is easy to miss the diagnosis in the early stage.

Therefore, clinically, for patients with diabetes and recurrent fever, abdominal ultrasound examination should be performed, and the possibility of liver abscess should be considered.

Diabetes mellitus
Treatment of liver abscess
After the diagnosis is clear, active anti-infective treatment should be given. Abscess puncture and drainage in the early stage of the disease, supplemented with local antibiotic treatment, can shorten the course of the disease and improve the prognosis.

If diabetic patients have poor blood sugar control and long-term high-sugar state, the chemotaxis, phagocytosis and bactericidal function of phagocytes will be impaired. Therefore, blood sugar must be controlled to prevent liver abscess.