Veratrole (CAS No. 91-16-7)

Catechol Dimethyl Ether
Pyrocatechol Dimethyl Ether

Molecular Formula: C8H10O2
Molecular Weight: 138.165


1, 2-Dimethoxybenzene, commonly known as veratrole, is an organic compound with the formula C6H4(OCH3)2. It is a colorless liquid with a pleasant odor and slight solubility in water.
It is the dimethyl ether derived from pyrocatechol, too.
1, 2-Dimethoxybenzene is naturally occurring. Its biosynthesis entails the methylation of guaiacol by guaiacol O-methyltransferase.1, 2-Dimethoxybenzene is an insect attractant.
Guaiacol O-methyltransferase gene is first scent gene discovered so far in any plant species.


1, 2-Dimethoxybenzene is a building block for the organic synthesis of other aromatic compounds. Veratrole is relatively electron-rich and thus readily undergoes electrophilic substitution. An example of the use of veratrole is in the synthesis of Domipizone.
Veratrole can easily be brominated with NBS to give 4-bromoveratrole.

Appearance White or Colorless to Almost white or Almost colorless powder to lump to clear liquid
Purity(GC) min. 99.0 %
Freezing point 21.0 to 23.0 °C
Properties (reference)
Melting Point 21 °C
Boiling Point 207 °C
Solubility in water Practically insoluble
Solubility (very soluble in) Ethanol,Ether,Benzene
Solubility (soluble in) Acetone