Don’t let hyperuricemia and diabetes go hand in hand

  Hyperuricemia is the culprit that causes gout attacks, and it has been widely known. Uric acid is the final product of purine oxidation in the human body. Purines in the body mainly come from cell metabolism and synthesis. The more purines in the body, the higher the level of uric acid. Where do the high levels of purines in the body come from? The answer given by scientists is inflammation. Inflammatory damaged cells release genetic fragments of DNA containing purines in the process of decay, and purines are metabolized to produce uric acid. Therefore, it can be said that the more cells that die in the body, the more purines are released and the higher the uric acid level. Under normal circumstances, the human body newly produces 600 mg of uric acid every day, excretes 600 mg of uric acid, and maintains a dynamic balance. However, once the production is excessive or the excretion is reduced, it will hurt itself and may cause hyperuricemia. According to reports, there are currently 170 million patients with hyperuricemia in my country and more than 80 million patients with gout.
  However, the harm of hyperuricemia is not just to cause gout. Hyperuricemia will also work hand in hand with metabolic diseases such as hyperlipidemia and diabetes to “make waves” in the body. This article will talk about hyperuricemia and diabetes.
  25% of patients with hyperuricemia
  male menopause, or women who have two fasting blood uric acid measurement value more than 420 micromoles / liter, non-menopausal women than 360 micromoles / liter, can be defined as hyperuricemia Blood disease. Hyperuricemia is often a prelude to gout attacks, but only about 10% of them will eventually develop acute gouty arthritis after a long period of about 15 years. Most people suffer from asymptomatic hyperuricemia, which has not attracted attention. This asymptomatic hyperuricemia known as the “fourth highest” can be described as a “silent killer” that sneaks into the human body. He was very sensual, and was embarrassed and embarrassed with the three-high syndrome.
  Studies have found that hyperuricemia is closely related to damage to multiple target organs. It not only damages human bones, joints, soft tissues, kidneys, pancreas, etc., but also urate crystals stimulate the inner wall of blood vessels and damage vascular endothelial cells. It also causes hypertension, diabetes, and arteries. Sclerosis, coronary heart disease, kidney disease and uric acid stones are one of the important “accomplices” that cannot be ignored. It has been reported that type 2 diabetes with hyperuricemia accounts for about 25%. Patients with coronary heart disease accompanied by hyperuricemia can increase their risk of death by more than 50%.
  Uremia caused by long-term hyperuricemia or repeated attacks of gout is not uncommon. A large number of studies have confirmed that hyperuricemia is an independent risk factor for type 2 diabetes, hypertension, arteriosclerosis, cardiovascular disease, and stroke. Some people think that hyperuricemia does not need to mind as long as gout does not occur. This view is very dangerous. The absence of symptoms of hyperuricemia does not mean that there is no damage to the tissues and organs of the human body. It’s just that this kind of damage is a long and silent process.
  Mr. Lin, a recently retired neighbor, has been suffering from type 2 diabetes for many years. The doctor changed him one hypoglycemic agent after another, and even used insulin, but the effect was still not obvious. One day I met me and told me about it. I opened his multiple blood biochemical examination reports and found that his blood uric acid level had been exceeding the standard. It seems that Teacher Lin not only suffers from type 2 diabetes, but also hyperuricemia. So he was asked to hang up the number of an expert in rheumatism and immunology. Since he added a small dose of the uric acid excretion drug benzbromarone, his blood sugar level reached the target soon, and he was very happy. I explained to him that uric acid metabolism and sugar metabolism are dependent on each other. When high urate is deposited in the islet cells, it will impair the function of the islets, which can easily induce insulin resistance, that is, the decrease in insulin sensitivity, forcing the pancreas to work hard to accelerate the production of insulin. As a result, hyperinsulinemia is caused, and the latter is the “culprit” in causing inflammation of tissues and organs throughout the body. Over time, the “bitter gourd” of type 2 diabetes will grow on this vine. It is reported that for every 1 mg/dL increase in blood uric acid, the relative risk of diabetes increases by 65%. On the other hand, type 2 diabetes is also prone to hyperuricemia. Diabetes leads to increased catabolism of purines and increases the production of blood uric acid. As the excretion of uric acid in the kidneys decreases, the blood uric acid level will increase. To put it bluntly, once hyperuricemia and diabetes go hand in hand, it is just like worsening the situation. Abnormal blood uric acid will cause “waves” in glucose metabolism. If hyperuric acid does not decrease, can blood sugar reach the target? Therefore, in addition to hypoglycemic, lipid-lowering, blood pressure, and anticoagulant therapy, patients with type 2 diabetes should also pay attention to the possible harm caused by hyperuricemia-the “fourth highest”.
  Detailed instructions for reducing hyperuricemia
  Experts pointed out that for people over 60 years old and suffering from diabetes, coronary heart disease, hypertension and other diseases, individualized medication should be used under the guidance of specialists to control hyperuricemia as soon as possible. Of course, changing bad diet and lifestyle is still a prerequisite for treatment.
  1. Drink water scientifically. Two-thirds of uric acid must be excreted through the kidneys. Drinking plenty of water can help dilute urine and accelerate the excretion of uric acid from the body. Drinking plenty of water can also inhibit the deposition of urate crystals in the kidneys and help reduce kidney damage. Drinking plenty of water can reduce blood uric acid levels. At least 2000ml or more is consumed every day to ensure that the urine output is about 2000ml per day. When drinking water, we must first advocate drinking alkaline water. It is better to use alkaline plain water and slightly alkaline, high-quality mineral water rich in trace elements and metasilicic acid, or soda water containing sodium bicarbonate. You can also add a small amount of non-polluting seawater dried crystalline salt to the water to help generate negative ion water; the latter can increase the body’s alkalinity, help reduce uric acid crystals, neutralize free radicals, and protect the integrity of cells. In addition, drinking black tartary buckwheat tea, light green tea, chia seed tea, etc. are also good choices. The second is to promote partial hydration and refrain from binge drinking. Binge drinking will increase the burden on the heart and kidneys. The best time to drink water every day is from morning to half an hour before breakfast, between breakfast and lunch, between lunch and dinner, and 45 minutes after dinner to bedtime. Drinking water before going to bed is beneficial to prevent the formation of urinary stones. It is better to drink water once at night.
  2. Try to remove high-purine foods from the table. Purine is a protein component that is broken down to form uric acid. The diet should minimize high-purine foods, such as anchovies, offal, herring, mackerel, sardines, shellfish, beef, lamb, roe, etc.
  3. Say goodbye to alcohol. Alcohol not only increases the body’s production of uric acid, but also reduces the amount of uric acid excreted from the body, causing a large amount of uric acid to accumulate in the body. Drinking beer can lead to increased blood uric acid, especially for people with beer belly. Hard liquors and wines with lower purines than beer are also best to drink less.
  4. Eat more fruits and vegetables. Vegetables and fruits are generally low-purine and mostly alkaline foods, such as lentils, celery, greens, lettuce, leeks, radishes, spinach, shepherd’s purse, kale, etc., and cherries, blueberries, strawberries, prunes, olives, plums, grapes, medlars It can alkalize body fluids and help dissolve and excrete urate.
  5. Other dietary precautions. Alkaline organic dairy products (such as low-fat milk, low-calorie yogurt without sucrose) can help reduce uric acid; coffee with alkaline ingredients can be consumed in moderation and has a protective effect. High-fructose-rich cola, carbonated drinks, functional drinks, fruit juices, candies, canned fruits, etc. should be eaten less or better avoided. Eat less baked pastries rich in fructose, such as donuts, cakes, croissants, biscuits, etc. The fructose content of honey is as high as 70%, so it is best to eat less. Because fructose is an important “accomplice” to prevent uric acid excretion and increase uric acid. In addition, excessive intake of fructose can cause fatty liver, which causes the liver and muscles to resist insulin.
  6. Insist on aerobic exercise. Swimming, cycling, jogging, and brisk walking, with the body sweating slightly, can excrete excessive free radicals in the body, maintain the body in a weak alkaline state, and help to lose weight and lose weight.