Name: Atropine sulfate
Synonyms: (8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenyl-propanoate sulphate
Molecular Formula: 2(C17H23NO3).H2SO4
Molecular Weight: 676.82
| Purity / Analysis Method | >99.0%(T) |
| Molecular Formula / Molecular Weight | C34H46N2O6·H2SO4·H2O = 694.84 |
| Physical State (20 deg.C) | Solid |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic |
| CAS RN | 5908-99-6 |
| Related CAS RN | 55-48-1; 51-55-8 |
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Solubility in Water | almost transparency |
| Melting Point | 194 °C |
| Solubility in water | Completely soluble |
| Solubility (very soluble in) | Alcohol |
| Solubility (insoluble in) | Chloroform,Ether |
Atropine Sulfate: A Nonselective Muscarinic Acetylcholinergic Receptors Antagonist
Atropine sulfate is a tropane alkaloid which was first extracted from the root of belladonna (Atropa belladonna) in 1830s. Atropine sulfate is a enantiomeric mixture of (R,S)-hyoscyamine (dl-hyoscyamine), racemization occurring during the extraction procedure, whereas only (S)-hyoscyamine (l-hyoscyamine) is the active isomer. Atropine is a competitive antagonist of muscarine-like actions of acetylcholine and is therefore classified as an antimuscarinic agent. Atropine does not distinguish among the M1, M2, and M3 subgroups of muscarinic receptors. Atropine inhibits the action of acetylcholine at postganglionic nerve endings, thus affecting receptors of the exocrine glands, smooth muscle, cardiac muscle and the central nervous system.
