Atropine sulfate

Name: Atropine sulfate
Synonyms: (8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenyl-propanoate sulphate

Molecular Formula: 2(C17H23NO3).H2SO4
Molecular Weight: 676.82

Purity / Analysis Method >99.0%(T)
Molecular Formula / Molecular Weight C34H46N2O6·H2SO4·H2O = 694.84
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Hygroscopic
CAS RN 5908-99-6
Related CAS RN 55-48-1; 51-55-8
Appearance White to Almost white powder to crystaline
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 99.0 %
Solubility in Water almost transparency
Properties (reference)
Melting Point 194 °C
Solubility in water Completely soluble
Solubility (very soluble in) Alcohol
Solubility (insoluble in) Chloroform,Ether

Atropine Sulfate: A Nonselective Muscarinic Acetylcholinergic Receptors Antagonist
Atropine sulfate is a tropane alkaloid which was first extracted from the root of belladonna (Atropa belladonna) in 1830s. Atropine sulfate is a enantiomeric mixture of (R,S)-hyoscyamine (dl-hyoscyamine), racemization occurring during the extraction procedure, whereas only (S)-hyoscyamine (l-hyoscyamine) is the active isomer. Atropine is a competitive antagonist of muscarine-like actions of acetylcholine and is therefore classified as an antimuscarinic agent. Atropine does not distinguish among the M1, M2, and M3 subgroups of muscarinic receptors. Atropine inhibits the action of acetylcholine at postganglionic nerve endings, thus affecting receptors of the exocrine glands, smooth muscle, cardiac muscle and the central nervous system.

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