A female scientist who came out of the Playboy Club

  Many people should have heard of such a magazine-“Playboy”, which was founded in 1953, claiming to include almost all the elements that men like: women, wine, cars, menswear and so on. As a magazine that occupies a blank space in the market, after its publication, its sales have risen steadily, and it has gradually become world-renowned, so that many Hollywood actresses are proud to be its cover characters.
  Under the leadership of this magazine, a series of extended industrial chains targeting men have been established, such as casinos and nightclubs. Countless middle and upper-class men have lived a life of drunken gold fans in these sales gold caves. In order to cater to their preferences, these places have also recruited many “high-quality” women, one by one, young, beautiful and elegant women wearing rabbits. Ears and a short tail, dressed up like the magazine logo to entertain male customers. How high is the “quality” of these women? After leaving Flower Boys, some of them became writers, some became medical scientists, and some became scientists, such as Polly Mazinger.
  From dropout to postdoctoral
  We know that some people have had success the United States drop out of school experiences, including Microsoft founder Bill Gates, Apple founder Steve Jobs, etc., and Polly have experienced drop out of school.
  Polly was born in a small city in southeastern France in 1947, and moved to California with her parents when she was 7 years old. Perhaps because her mother was a nun and her father had experience in concentration camps, the couple held a free and democratic attitude towards Polly’s education, allowing her to independently decide her future direction of life. Polly chose to break into society when she was in college. She dropped out of the University of California, Irvine and started a part-time career. With a dream of being a star, Polly aspires to become a jazz singer. In order to support her dream, she has worked as a bartender and a dog trainer, but it is a pity that she eventually failed to meet a scout with wit.
  As a mixed race, Polly, who has an outstanding appearance and speaks several foreign languages, was introduced to the most famous nightclub at the time, the Playboy Club, and became a waiter. Here, she received the highest salary so far and opened the door to a new world. The Playboy Club brought together many top celebrities. While Polly was entertaining them, she also listened with relish to all kinds of topics they talked about and learned a lot about things she didn’t know before.
  Once, Polly hosted two biology professors from the University of California, Davis, who came to visit frequently, and listened to them talking about the mimicry of butterflies, which is a survival strategy of living creatures. Look like to avoid hunting by hunters. Polly listened and couldn’t help but interjected: “Why is there never an animal mimicking skunk?” Upon hearing this novel question, one of the professors turned his head and looked at the pretty little girl, and gave Such a comment: “Your logic of thinking is actually more suitable to be a scientist than a waiter.” Faced with such an evaluation, Polly thought he was just joking, but he didn’t expect the professor to be serious. When he came to drink later, he would bring Polly several well-known scientific magazines such as “Nature” and “Scientific American” to instill scientific knowledge and arouse her interest.
  After the professor persisted for 9 months, Polly was persuaded and she decided to return to school. Polly completed her undergraduate studies in biology at the University of California, Irvine, then got her Ph.D. at the University of California, San Diego, and did a post-doctorate program at the University of Cambridge in the United Kingdom. Finally, she went to the National Health Center in Maryland, the United States. Research Institute.
  Laboratory model with the specter of danger
  in school Polly still very personal, her choice is a premier specialty – Cellular and Molecular Immunology. Unlike other biology majors, immunology pays more attention to theory and review rather than experiments. Therefore, Polly’s laboratory often only has tables and chairs instead of various experimental equipment. Because of the “emptiness” of the laboratory, Polly nicknamed her immunology laboratory the “ghost laboratory”. It is here that Polly “fantastically” came up with her most well-known theory, the danger model, and explained for the first time some unresolved problems in immunology.
  Before Polly, the most well-known immune theory was undoubtedly the “self-different model” proposed by the founder of immunology, Peter Medavo, which is also the most widely known immune theory today. This theory believes that the immune system can recognize non-self-derived substances to initiate an immune response, such as bacterial virus infection or organ transplantation, the immune system can recognize the “non-self” part and drive out the “invaders”.
  But soon, immunologists realized that this model has many unexplainable problems. For example, for women, male sperm and implanted embryos are both “non-self” parts. Why doesn’t the mother reject these cells? We come into contact with foreign objects from the air, water, and food every day, and even the digestive tract is full of bacteria. Why can these foreign objects “coexist harmoniously” with us? How should “foreign body” be defined? On the basis of reading a large number of predecessors’ literature, Polly put forward a brand-new theory, the “danger model” through her own thinking. She believes that not all foreign bodies trigger an immune response, and only those foreign bodies that send out a “danger signal” and are perceived by the human body will trigger an immune response. After papers related to the hazard model were published in top journals such as “Nature” and “Science”, it caused extensive discussion, and many immunologists began to support the hazard model.
  The danger model is enough to make Polly a famous scientist, but she is not satisfied with it. Recently, Polly began to search for dangerous substances and red flags in the “ghost laboratory”. Polly believes that the most widespread danger signal is the hydrophobic part of the molecule (that is, the structure that is insoluble in water). When the hydrophobic part of the molecule is exposed, the danger signal is sent out. This is because life originates from water, and most of the physiological reactions in organisms also occur in liquids. In order to adapt to life in water, biomolecules usually undergo a folding process to hide the hydrophobic part inside the molecule or in the cell membrane. And if the hydrophobic part of a molecule is exposed, it will be easily distinguished from other molecules, be recognized from the system, and then be rejected.
  Prejudice and unyielding struggle of the world
  for Polly, the significance lies not only confirmed the danger theory made himself known scientists, it has even become the only business card “People can talk and I’m good science”.
  In a documentary filmed by the BBC for Polly, she talked about the impact of her experience as a waiter at the Playboy Club on her. When she first entered the academic world, she talked with anyone “it takes a while to get on the right track of scientific topics.” Almost everyone has expressed such doubts explicitly or secretly, how can a waitress do it? What about scientific research? Even the documentary itself, compared to her immunity theory, seems to be more curious about the identity of her former waitress.
  But fortunately, Polly has a healthy mentality and a strong personality. Faced with the BBC’s malicious scenes, she smiled faintly: “Playboy Bunny is part of my life experience. But now, in addition to Playboy, people are more willing to talk to me. Science.” Polly’s confidence comes from the uniqueness of her thinking.
  This uniqueness can be seen in her thesis. Usually, a scientific paper will have many authors, but Polly’s essay is uncharacteristically. Either she is the only author or her pet dog is added. When Polly was little known, she submitted an article to the well-known medical journal “Journal of Experimental Medicine”, and the article only signed her own name. The editor believed that the paper had only one author and the conclusion was not reliable, so he returned the manuscript to her. Afterwards, Polly added an author to the paper, and soon the paper was published.
  Later, a classmate of Polly told a joke to her father, the editor-in-chief of Journal of Experimental Medicine: “Do you know who the author behind Polly’s article is?” The editor-in-chief said, “It’s not her.” The editor’s mentor?” The editor’s daughter laughed and revealed the truth: “That’s Polly’s puppy—the name of an Afghan hound!” 15 years of rejection, but she still maintains her uniqueness-there are still no more than three authors of her article.
  The maverick Polly never cares about the eyes of others. No matter how many people have seen her research results with tinted glasses, she always keeps a sweet smile and works harder to respond to those who question her with the results. And all this stems only from her strong interest and deep love for science. Polly’s experience tells us that as long as there is interest, it is never too late to start.