Why do patients with liver cirrhosis need to check the coagulation function

Cirrhosis itself is a chronic disease. During the onset, the patient’s liver will continue to deform and harden, which can lead to chronic liver damage. Affected by this, most patients have gastrointestinal bleeding, hepatic encephalopathy and other manifestations, and some patients will also have symptoms such as infection of bacteria, hypersplenism, ascites, and cancer.

As a common clinical examination, the coagulation function test contains many indicators, and its function in the indicator represents the ability of the fluid to change from a flowing state to a non-flowing coagulation state. During the examination of patients with liver cirrhosis, doctors often arrange for the patient to have a blood coagulation function test.

Index of coagulation function test
When the human blood vessels are damaged, the coagulation factors will be activated in a certain order. This process will generate a certain amount of thrombin. Thrombin will act on fibrinogen to turn it into fibrin and eventually cause blood to coagulate. In clinical practice, coagulation function test is a kind of examination of blood coagulation ability. From the perspective of clinical practice, the coagulation function test not only includes thrombin time, but also involves prothrombin time and fibrinogen. In addition, partial thromboplastin is also an important test index. Among these inspection indicators, prothrombin time is the main indicator that people need to check. It represents the actual ability of the human body’s extracorporeal blood coagulation system. When the human body has congenital coagulation factor deficiency or liver disease due to vitamin K deficiency , The prothrombin time will be prolonged, and when the human congenital coagulation factors are in a hypercoagulable state, and the patient has blood clots and other diseases, the prothrombin time will gradually shorten. At this stage, coagulation function examination should become a more commonly used clinical examination item, and it is widely used in the examination of coagulation dysfunction diseases such as hemophilia. In addition, in patients with liver disease, the application of coagulation function test is also more.

The role of coagulation test
For normal people, their coagulation function is within the normal range, and the coagulation process is relatively stable. When the coagulation function is abnormal, it tends to develop in two directions: (1) the coagulation ability is too high, this condition is easy to block the blood vessel, and then form a thrombus in the hypercoagulable state; (2) when the coagulation function is too low Or when it is insufficient, the amount of bleeding in the patient’s blood vessel damage will increase, which increases the risk of patient injury. In life, whether it is thrombosis or bleeding, patients should pay attention to the coagulation function test, and in the coagulation function test, the observation of platelet level should be paid attention to. The number of platelets is an important factor affecting bleeding and coagulation. When the number of platelets is abnormal, it can indicate to a certain extent that the patient’s coagulation function is abnormal. It is worth noting that the coagulation process itself is more complicated. In addition to platelets, there are 12 other factors involved in coagulation. The absence of any factor will cause bleeding in the patient. For example, hemophilia is a relatively common abnormal bleeding problem in life. The appearance of this disease is related to the shortage of coagulation factor VIII. In clinical practice, doing a good job of coagulation function examination has a positive effect on mastering the patient’s coagulation ability and sub-aided diagnosis of related diseases. Based on this, in the disease examination, an effective examination of the coagulation function should also be done in accordance with the doctor’s advice.

For patients with liver cirrhosis, the number of platelets is small, which makes their own blood coagulation disorder, and problems such as anemia due to excessive bleeding occur, which greatly endangers the patient’s life safety. As far as platelets are concerned, when they adhere to the vascular injury site, the platelets will adhere to denature and aggregate with each other to form an initial hemostatic thrombus to help patients achieve wound coagulation. At the same time, under the effect of membrane phospholipid metabolism, platelets will produce certain phospholipid metabolites. These metabolites will accelerate the release reaction of platelets. To a certain extent, it makes the platelets aggregate faster and effectively plays the role of coagulation at the injured site. At the same time, it can promote vasoconstriction and blood clot contraction, which effectively ensures the integrity of vascular endothelial cells.

When suffering from liver cirrhosis, affected by portal hypertension, the patient’s spleen enlarges. At this time, there is more blood storage in the spleen, which makes the platelets in the spleen gradually stagnate. Affected by this, the phagocytic cells in the spleen With increased activity, these phagocytes will have an effect on platelets, and eventually the number of platelets in the human blood will continue to decrease, which affects the body’s blood coagulation function. Based on this, for patients with liver cirrhosis, the discovery of their specific blood coagulation status through coagulation function examination has a profound impact on the later diagnosis and treatment of the disease. Studies have shown that coagulation dysfunction in patients with liver cirrhosis can be roughly attributed to two reasons: (1) As far as coagulation factors are concerned, their main components are proteins. These proteins are synthesized in the human liver. When suffering from cirrhosis, liver function is impaired. , Which hinders the function of protein synthesis and eventually leads to insufficient coagulation factors. (2) Vitamin K plays an important role in the synthesis of coagulation factors. However, for patients with liver cirrhosis, it cannot achieve the effective use of vitamin K, which affects the synthesis of coagulation factors, and eventually patients will have more serious coagulation dysfunction. problem. It can be seen that, for patients with liver cirrhosis, it is very important to do a good job of coagulation function examination, which can provide an effective reference for the cause of spontaneous bleeding and subcutaneous hemorrhage in patients with liver cirrhosis and the diagnosis and treatment of diseases.

All in all, the coagulation function test has a profound impact on the diagnosis and treatment of patients with liver cirrhosis. In clinical practice, patients with liver cirrhosis can only fully realize the role of coagulation function examination and then perform standard examination of coagulation function in accordance with the doctor’s order. This can improve the quality of coagulation function examination and create favorable conditions for the diagnosis and treatment of patients with liver cirrhosis.