Ipidacrine Global Buyers List: A Strategic Sourcing Guide
Ipidacrine (also known as Amiridine, NIK-247, CAS 62732-44-9) is a potent cholinesterase inhibitor and nootropic agent with significant therapeutic potential in the treatment of Alzheimer’s disease and other cognitive disorders . As a reversible inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of approximately 1 μM and 1.9 μM respectively, it also functions as a partial agonist at M2-cholinergic receptors and stimulates neuromuscular transmission . Available in multiple forms including free base, hydrochloride salt, and hydrochloride monohydrate, ipidacrine serves both the pharmaceutical research and finished pharmaceutical product markets . Understanding the global buyers list is essential for API suppliers, research chemical distributors, and manufacturers seeking to expand their reach in this specialized pharmaceutical segment.
Understanding the Ipidacrine Market Landscape
Ipidacrine is distinguished by its ability to rapidly penetrate the blood-brain barrier, with high drug levels observed in the cortex and hippocampus within five minutes of oral administration . It demonstrates efficacy in various animal models of amnesia, suggesting its utility as a therapeutic candidate for Alzheimer’s disease . Additionally, it has shown potential in treating conditions including ischemic stroke, facial neuropathy, and diabetic erectile dysfunction . The compound is classified under ATC code N06DA05 as an anti-dementia drug .
Product Specifications
Key Application Segments
| Sector | Applications | Key Forms |
|---|---|---|
| Pharmaceutical Research | Alzheimer’s disease studies, cognitive enhancement research, neuroprotection | Free base (98%+), high-purity reference standards |
| Finished Pharmaceutical Products | Anti-dementia therapy, neuromuscular stimulation, analgesic applications | Tablet formulations (20mg), injectable solutions (5mg/mL, 15mg/mL) |
Key Ipidacrine Buyer Countries and Regions
Russia and CIS Countries: Documented Pharmaceutical Markets
The most significant documented markets for ipidacrine are in Russia and other CIS nations, where finished pharmaceutical products containing the compound are registered and distributed. Neuromidin (Ипидакрин) is a commercially available tablet formulation containing 20mg of ipidacrine hydrochloride, with distribution confirmed in the Kyrgyz market . Additionally, Ipigrix (Ипигрикс) injectable solutions containing 5mg/mL or 15mg/mL ipidacrine are available in the Kyrgyz market . These established product registrations indicate a mature distribution network across the region.
Global Research Chemical Market
The global research chemical sector represents a significant buyer segment for ipidacrine. Multiple international suppliers and distributors serve this market:
- TargetMol (US/Global): Supplies ipidacrine (CAS 62732-44-9) at 99.99% purity for research applications, with availability in 25mg and larger quantities .
- Solarbio (China/Global): Offers ipidacrine at ≥98% purity in 100mg and 500mg sizes for research use .
- Bidepharm (China): Supplies ipidacrine hydrochloride monohydrate at 97% purity in 250mg to 25g quantities .
- MolCore (China/Global): Provides ipidacrine hydrochloride at ≥98% purity with ISO certification .
- SynZeal (Global): Specializes in ipidacrine reference standards and impurities for regulatory and quality control applications, including ANDA and DMF filings .
- MCE (MedChemExpress) (Global): Distributes ipidacrine hydrochloride for research purposes .
Additional Documented Markets
- United States: Research chemical distributors serve the US academic and pharmaceutical R&D market.
- China: Manufacturing and distribution base with multiple suppliers exporting globally.
- European Union: Research chemical importers and pharmaceutical R&D customers.
- Japan: Kisco Limited and other distributors serve the Japanese research market.
Notable Ipidacrine Buyers and Importers
Based on product registrations, supply chains, and trade documentation, the following categories of buyers have been identified:
Finished Pharmaceutical Product Distributors and Buyers
| Entity | Region | Product Type | Source/Manufacturer |
|---|---|---|---|
| Neuromidin (brand) | Russia/CIS | 20mg tablets | Documented product registration |
| Ipigrix (brand) | Kyrgyzstan | 5mg/mL, 15mg/mL injectable | Documented product registration |
Research Chemical Distributors and End-Users
Pharmaceutical API and Finished Product Manufacturers
| Entity | Region | Role |
|---|---|---|
| Multiple manufacturers (undisclosed) | Russia/CIS | Finished product manufacturers |
| Various Indian manufacturers | India | Potential API and formulation suppliers |
| Chinese manufacturers | China | API and research chemical producers |
Regulatory and Compliance Considerations
For companies looking to buy or sell ipidacrine, several key factors determine success in this specialized market.
- Regulatory Status: Ipidacrine is an approved pharmaceutical ingredient in Russia and certain CIS countries, where finished products such as Neuromidin and Ipigrix are registered. In most other regions, it is sold exclusively for research purposes and is not approved for human therapeutic use .
- Documentation Requirements: Research chemical buyers typically require Certificates of Analysis (CoA), HPLC purity data, and proper safety documentation . API buyers for pharmaceutical manufacturing require additional documentation including stability data and regulatory compliance certificates.
- Supply Chain Intelligence: SynZeal’s availability of reference standards indicates a regulatory compliance market segment supporting ANDA and DMF filings, suggesting ongoing pharmaceutical development activities involving ipidacrine .
- Storage and Handling: Ipidacrine products require specific storage conditions. Free base material should be stored at -80°C, protected from light . Hydrochloride monohydrate forms require storage at 2-8°C . Buyers should ensure adequate storage capabilities before procurement.
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Conclusion
The Ipidacrine global buyers list represents a specialized market segment spanning finished pharmaceutical distributors in Russia and CIS countries, research chemical suppliers in the United States and China, and research institutions worldwide. With documented buyers including Neuromidin and Ipigrix distributors in Kyrgyzstan, and suppliers such as TargetMol, Solarbio, and SynZeal serving the global research community, opportunities exist for both API suppliers and research chemical distributors.
Sourcing success hinges on understanding the regulatory framework in target regions, selecting the appropriate chemical form (free base, hydrochloride salt, or monohydrate), and ensuring proper documentation and storage conditions. By focusing on quality assurance, regulatory compliance, and strategic market targeting, stakeholders can thrive in this specialized pharmaceutical research and development market.
