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Sharpless, 81, wins second Nobel Prize in 21 years

   After 21 years, 81-year-old Barry Sharpless (also translated as Sharpless) won the Nobel Prize in Chemistry for the second time. In the more than 100-year history of the Nobel Prize, only four scientists have been awarded twice before, and only one of them has won the Chemistry Prize twice. Today, Sharpless becomes the fifth scientist to win the Nobel Prize twice.    In 2001, for his contribution to chiral catalytic oxidation, Sharpless shared the Nobel Prize in Chemistry with two other scientists, and he won half of the Nobel Prize in Chemistry
   .
As early as 1998, the 57-year-old Sharpless almost gave up his Nobel Prize-winning discovery and “easy” into a new field – click chemistry.
   Click chemistry is a functional form of chemistry in which molecular building blocks are brought together quickly and efficiently. Before the theory of click chemistry was proposed, the field of organic chemistry had a soft spot for carbon-carbon bonds, because such bonds were truly unique in their ability to synthesize for chemistry whose mission was to create new substances. However, the synthesis of carbon-carbon bonds is very difficult and expensive, and scientists who go this route have to design more complex chemical experiments.
   Sharpless argues that innovation at the highest level is not improving what is already there, but giving what people want but don’t realize. Even if you have won a Nobel Prize, don’t blindly follow your original self. Only in this way can you encounter the next “Noble Prize-level discovery”.
   Sharpless’s “turn” has affected the entire chemistry world, and click chemistry has now become one of the most attractive synthetic concepts, widely used in organic chemistry, polymer material synthesis, biomolecular labeling, antibody modification, drug development, etc. A series of important research and production areas.
   Taking the initiative to hand over the “olive branch” to absorb nutrients
   from Different from the introduction of Nobel Prize winners by domestic research institutions, Sharpless’s connection with China is the “olive branch” he handed over voluntarily, which shows his love for China. Sharpless is optimistic about China for three reasons: first, his most proud disciple is Chinese; second, Shanghai has the world’s top fluorine chemistry; third, he has many old friends in China.
   This may be the true portrayal of “plant the plane tree, the phoenix will come naturally”. As early as 2015, Sharpless sent an email to Dai Lixin, an academician of the Chinese Academy of Sciences and a researcher at the Shanghai Institute of Organic Chemistry, hoping to work at the Shanghai Institute of Organic Chemistry. This is because Shanghai Organic has one of the world’s leading fluorine chemistry research forces, and the development of click chemistry requires fluorine-containing compounds.
   In Shanghai, he and his disciple Dong Jiajia jointly published the second-generation click chemistry-hexavalent sulfur-fluorine exchange reaction (SuFEx). Prince” is an active protein structure.
   Sharpless likes Chinese culture very much, especially a sentence in Lao Tzu’s “Tao Te Ching”: “Therefore, what is useful is beneficial, and what is not is useful.” He believes that this expresses the true philosophical meaning of “click chemistry”: The reactive carbon-heteroatom combination may seem useless, but with special functional groups, it can have high selectivity. Therefore, useless things often contain great value, and it is necessary to be good at seeking “big use” from uselessness.
   Willing to try everything, “Scientific urchin” does the purest chemistry. In
   life , this leading scientist is as frank as a child. Don’t care about meal times. As long as someone chatted with him about chemistry, especially click chemistry, he would be very excited and dancing.
   While at MIT in the 1970s, Sharpless was checking out a student’s experiments when a problem with the encapsulation of his NMR tube exploded, shattering the cornea of ​​one of his eyes. , causing him to work with only one eye for the rest of his scientific career. I heard that Sharpless also has a hobby: he likes to taste the compounds synthesized by himself and his students, which is comparable to “Shen Nong tasting all kinds of herbs”.
   “I don’t know when the dawn will come, I open every door and window.” This is Sharpless’s favorite verse, and it also reflects his scientific outlook. If he has more serendipitous discoveries than others, it is because he will try everything he can and delete the word failure from his mental dictionary.
   Six years ago, Sharpless decided to dedicate his final scientific career to Shanghai. Today, he has his own laboratories in several institutions in Shanghai, and has reached close cooperation with Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai University of Traditional Chinese Medicine and other hospitals in the fields of pathogenic mechanism and new drug discovery.

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