The recombinant strain XE flashed

More recently, WHO has sounded the alarm about a new variant of Omicron called XE, a recombination of BA.1 and BA.2. XE could be as much as 10 percent more potent than ba.2, the group said. Does this mean an unprecedented “super-strong strain” has emerged?
The recombinant variant of XE was first detected in the United Kingdom on January 19, 2022. As of March 25, 637 cases of XE were detected in the United Kingdom. But the dominant strain in the UK is still Omicron BA.2, which has accounted for about 93.7 per cent of cases in England since February.
Genetic sequencing showed that a small portion of the XE gene was derived from the original omicron strain BA.1, while most of the rest came from BA.2, especially the gene for the S protein, a key part of the virus that binds to the host. Therefore, preliminary studies suggested that the transmission characteristics of the virus were more similar to that of BA.2 from the perspective of virus structure, and the symptoms of infected persons were similar to that of BA.2. The recombinant strain is different from the mutant strain. Jin Dongyan, a virologist at the University of Hong Kong, explained to reporters that the conditions for the birth of recombinant strains are “very harsh”. Two strains must infect a cell at the same time, and both strains are active in the cell before it is possible to recombine. “The probability itself is very small because even if the interval between infections is slightly longer, if a person is infected with ba.1 first, the body’s immune system quickly produces antibodies, and by the time it infects ba.2, the BA.1 may have been killed.”
Currently, in addition to XE, two other recombinant variants have been detected in the UK: XF and XD, both of which are recombinant variants of Delta and BA.1.
“Novel coronavirus recombinations and mutations are happening all the time.” Jin Dongyan observed that since the outbreak, there have been thousands of mutant strains, hundreds of thousands of recombinant strains, most of them seems to be a flash in the pan, quietly disappeared, from alpha to Mr Mick Dijon, mutant strains, instead of recombinant strains, in fact, the recombinant strains there was not one to stay. “Why is that? Since the recombinant variant is inbred, its transmission characteristics cannot be significantly different from those of the parent strain, meaning that Monkey King cannot escape Buddha’s grasp at all.”
“The overall evolutionary trend of novel Coronavirus must be towards greater transmission but less virulence,” Said Prof Jin. In the process of human and virus fighting each other, they are in coevolutionary, human beings through vaccination and to obtain antibody, virus tries to bypass the antibodies in order to survive, will be more and more flexible, “as the game continues, there is always a new advantage variant strains to replace Mr Mick Dijon, like the dense gram si replace delta, It’s the natural course of virus evolution, and it’s just a matter of time.”
It is important for humans to keep track of the evolution of viruses. Although there is no need to panic about XE, its genetic sequence needs to be continuously monitored, as well as for other recombinant and mutated strains. Surveillance to enable rapid response to COVID-19 and provide decision-making support for timely vaccine updates.
Experts say the priorities for the next stage are clear: vaccinating the elderly and those at high risk of immunodeficiency as soon as possible.

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