Fatty liver for weight loss in vitro

  This year, it is really not easy for those waiting for organ transplants. Not to mention that there are not many people who donate organs, and the organs that are finally donated may not be qualified. For example, in the UK, a large part of the donated liver is fatty liver. The so-called fatty liver is the accumulation of excessive fat in liver cells. Nine out of ten obese people suffer from fatty liver. Fatty liver cannot be used for liver transplantation, and it is generally thrown away in the end.
  However, what if the fatty liver is allowed to “weight loss” outside the body? Can it be used after weight loss? Yes, a British research team has developed a method that can effectively make fatty liver lose weight quickly.
  They did this by using two drugs, one called adenylate cyclase and the other called L-carnitine. These two drugs promote the release of fat from liver cells. Scientists first set up an artificial blood circulation for the isolated liver, and then dissolve the two drugs in the blood. After the drug reaches the liver, it prompts the liver cells to release fat into the blood, and then filters the fat particles in the blood through the machine, so that the liver can lose weight.
  In 2018, the research team used this method to successfully lose weight to 16 fatty livers, making them reach the standard for transplantation. This is the first time that human organs have been treated outside the body.
  Others are trying different methods. For example, Dutch scientists tried to heat the liver to 40 degrees Celsius to increase its metabolic rate and make it burn more fat.
  Fatty liver is not the only disease that can be treated in vitro. Treatment of organs in vitro is more convenient for cell or gene therapy than treatments in vivo, so that it will not trigger an immune response in the patient. We know that the immune response is sometimes very dangerous. For example, for people who died of the new pneumonia virus this time, most of them died not directly from the virus infection, but from the overreaction of their own immune system. Because once the reaction is overdone, the immune system will not only kill the virus, but also a large number of healthy cells, and the patient may die from organ failure.